Freshman Emily Engstler led the team with a career-high 17 points.
Elijah Hughes led the Orange in scoring with 18 points.
The Orange went on a 24-11 run in the fourth quarter to seal the victory for Syracuse.
NC State went on two separate scoring runs in the second half, resulting in a combined 21-0 for the Wolfpack.
The Orange shot 36.6 percent in field goals, while NC State shot 41.7 percent.
Miranda Drummond sunk six three-pointers in her season-high 24 points.
Buddy Boeheim finished with a career-high 16 points.
The Orange faced a 28-point deficit going into the fourth quarter.
The Seminoles went on a 12-0 run late in the second half to seal the victory for No. 25 Florida State.