Oshae Brissett scored a team-high 16 points.
Elijah Hughes scored a game-high 22 points and hit six of his nine three-point attempts.
Kiara Lewis comes off the bench to score a team-high 16 points and made some exceptional plays.
The Orange only made 19 percent of their shots beyond the arc.
The Orange shot 46 percent from deep.
Digna Strautmane shot 78 percent in field goals and 80 percent in three-pointers to lead the Orange to another victory.
Tyus Battle finished with a season-high 32 points, the most ever by a Syracuse player against Duke.
Tiana Mangakahia scored 34 points and had 10 rebounds and 10 assists.
Georgia Tech went on a 22-7 scoring run in the first eight minutes of the second half to dominate the Orange.