Digna Strautmane shot 78 percent in field goals and 80 percent in three-pointers to lead the Orange to another victory.
Tyus Battle finished with a season-high 32 points, the most ever by a Syracuse player against Duke.
Tiana Mangakahia scored 34 points and had 10 rebounds and 10 assists.
Georgia Tech went on a 22-7 scoring run in the first eight minutes of the second half to dominate the Orange.
The Orange outscored Clemson 30-22 in the first half to give Syracuse a stable lead for the rest of the game.
Tiana Mangakahia scored a season-high 27 points.
Bourama Sidibe made big plays after Syracuse big men Marek Dolezaj and Paschal Chukwu fouled out.
Buddy Boeheim scored a career-high 12 points.
This is the Orange’s first win since the Dec. 8 contest against Georgetown.