The Orange went on a 24-11 run in the fourth quarter to seal the victory for Syracuse.
NC State went on two separate scoring runs in the second half, resulting in a combined 21-0 for the Wolfpack.
The Orange shot 36.6 percent in field goals, while NC State shot 41.7 percent.
Miranda Drummond sunk six three-pointers in her season-high 24 points.
Buddy Boeheim finished with a career-high 16 points.
The Orange faced a 28-point deficit going into the fourth quarter.
The Seminoles went on a 12-0 run late in the second half to seal the victory for No. 25 Florida State.
Oshae Brissett finished with 18 points and 12 rebounds.
Tiana Mangakahia led the Orange with 16 points and 14 assists.