Miranda Drummond sunk six three-pointers in her season-high 24 points.
Buddy Boeheim finished with a career-high 16 points.
The Seminoles went on a 12-0 run late in the second half to seal the victory for No. 25 Florida State.
The Orange faced a 28-point deficit going into the fourth quarter.
Oshae Brissett finished with 18 points and 12 rebounds.