The Orange came back after a sloppy first half to score 50 points against the Hoyas.
Strautmane had a game-high 17 points.
Sophomore forward has his best game of the young season with 21 points and 14 boards, dominating Northeastern 72-49.
The Orange will face No. 16 West Virginia.
Miranda Drummond and Tiana Mangakahia recorded double-doubles to help Syracuse defeat Towson.
Tyus Battle scored a season-high 26 points against the Big Red.
Commentary: The Orange should be gearing up for a trip to Disney World.
The Orange defeated the Bulldogs 3-0 (25-22, 25-21, 25-16).